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In its early days, sequencing was a laborious (and literally radioactive) biochemical process. Today, sequencing machines are ubiquitous, safe, and much less labor-intensive. This evolution was enabled not just by advances in biochemistry but insights from biophysics and materials science, as well as manufacturing ingenuity that turned lab sequencing setups into machines ready for shipping to customers.

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Agar was first introduced into the laboratory in 1881. Since then, microbiologists have depended on agar to create strong jellies. When microorganisms are streaked or plated onto this jellied surface and incubated, individual cells multiply into distinct colonies that scientists can easily observe, select, and propagate for further experiments. Many of the most important findings in biological research of the last 150 years or so — including the discovery of the CRISPR/Cas9 gene-editing tool — have been enabled by agar.4 Agarose, a derivative of agar, is also essential in molecular biology techniques like gel electrophoresis, where its porous gel matrix separates DNA fragments by size, enabling researchers to analyze and isolate specific genetic sequences.