The problem compounds in pipelines. Each TransformStream adds another layer of promise machinery between source and sink. The spec doesn't define synchronous fast paths, so even when data is available immediately, the promise machinery still runs.
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Now, three researchers at the University of Pennsylvania, Alexander Platt, Daniel N. Harris, and Sarah Tishkoff, have done the converse analysis: examining the X chromosomes of the handful of completed Neanderthal genomes we have. It turns out there's also a strong bias toward modern human sequences there, as well, and the authors interpret that as selective mating, with Neanderthal males showing a strong preference for modern human females and their descendants.